Furthermore, the proneural type of GBM, defined by mutations in isocitrate dehydrogenase (IDH) and the accumulation of oncometabolite 2-hydroxyglutarate (2-HG), shows increased expression of several VM-related proteins such as VE-cadherin, HIF-1α, and EphA2 [124]. Here, CDH5 is linked to glioblastoma.