Polymorphisms in the IL1A (rs17561 and rs1800587), ACE2 (rs35697037, rs2074192, and rs879922), IL1B (rs1143634), IL10 (rs1800896 and rs1800872), and IL8 (rs2227306) genes were also crucial genetic factors for predicting mortality associated with rehospitalization in the first year following the first COVID-19 diagnosis (Figure 4A). This evidence concerns the gene CXCL8 and COVID-19.