The results revealed that polymorphisms in the IL6, IL6R, IL1α, IL1R, IFNγ, TNFα, CRP, VDR, VDBP, and ACE2 genes are the most significant genetic factors influencing COVID-19 prognosis, particularly in terms of the risks of COVID-19 pneumonia, mortality, rehospitalization, and associated mortality. This evidence concerns the gene ACE2 and COVID-19.