Nineteen genetic variants in ten different genes were the most influential in COVID-19 prognosis, particularly IL6R (rs2228145), IL6 (rs1800797 and rs1800796), CRP (rs2794521 and rs1800947), IFN-γ (rs2430561), IL1A (rs17561 and rs1800587), TNF-α (rs1800629), IL1R (rs419598), ACE2 (rs35697037 and rs2285666), VDR (rs1544410, rs7975232, and rs2228570), and VDBP (rs7041, rs2282679, and rs4588). This evidence concerns the gene IL1A and COVID-19.