In this context, our results identified polymorphisms in genes such as IL6, IL6R, IL1A, IL1R, IFN-γ, TNF-α, CRP, VDR, VDBP, and ACE2 as the most significant genetic factors influencing COVID-19 prognosis, especially regarding the risks of COVID-19 pneumonia, mortality, rehospitalization, and related mortality. This evidence concerns the gene TNF and COVID-19.