PACS2 and developmental and epileptic encephalopathy, 66: Beyond their diagnostic potential, the frequent co-identification of SHMS with Developmental and Epileptic Encephalopathy 66 (DEE66, linked to PACS2 variants) and Neuro-Oculo-Cardio-Genitourinary syndrome (NOCGUS, caused by WDR37 variants) suggests notable facial similarity despite distinct molecular etiologies.