Likewise, in non-small cell lung cancer (NSCLC), frameshift mutations in ND6 (e.g., 13885insC) upregulate the VEGF, CXCL12, and MMP-9, promoting EC recruitment, extracellular matrix remodeling, and metastatic neovascularization [65]. This evidence concerns the gene MT-ND6 and non-small cell lung carcinoma.