TP53 and non-small cell lung carcinoma: In p53-mutant or -deficient cells (e.g., the NSCLC line H1299), intracellular LA-12 binds with high affinity to the molecular chaperone Hsp90 (50 μM LA-12: 0.222 mg Pt/mg protein vs. <0.02 mg Pt/mg protein for Cisplatin).