A recent study revealed that the knockdown of the lactate dehydrogenase A (LDHA) protein could reduce histone lactylation levels at the HMGB1 promoter, as well as decrease the expression levels of IL-18, IL-1β, cleaved caspase-1, and GSDMD-N proteins in both in vivo and in vitro models of cerebral ischemia/reperfusion. The gene discussed is LDHA; the disease is brain ischemia.