MEG3 and early-onset autosomal dominant Alzheimer disease: Dysregulation of MEG3 lncRNA expression in Alzheimer’s disease plays a critical role in disease progression by influencing necrosis and apoptosis processes in neuronal cells; recent studies have further identified MEG3 as a key regulator of neuronal necroptosis, highlighting its potential role in human-specific neuronal vulnerability and offering novel therapeutic targets [14,15].