ERBB2 and breast carcinoma: Breast cancer, common in women, usually begins in the milk ducts or lobules and is associated with (Breast Cancer Gene) BRCA gene mutations, hormonal imbalances, and overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) (Figure 2) [22], with over 300,000 cases and 40,000 deaths presented in 2024 [23].