The IL-8–CXCR1 axis is worth mentioning because it is believed to be crucial for maintaining the stem cell-like features of breast cancer [37]; treatment with recombinant IL-8 led to enriched BCSCs, characterized by increased ALDH1 expression, mammosphere-forming efficacy, and greater invasive capacity [4]. This evidence concerns the gene CXCL8 and breast carcinoma.