The latter has been shown to act as a potent chemoattractant for neutrophils which are also within the GC microenvironment, promoting the recruitment and polarization of TANs toward a pro-tumor N2 phenotype, which is characterized by high expression of programmed death-ligand 1 (PD-L1) [18,19,20,79,80,81]. This evidence concerns the gene CD274 and neoplasm.