Vehicle group exhibited significant splenomegaly and elevated MPO activity compared to healthy controls (p < 0.0001 and p < 0.05, respectively) While monotherapies with CBD or lower dose CSA were largely ineffective, combination treatment with 10 mg/kg CBD and either 2.5 mg/kg or 5 mg/kg CSA significantly reduced relative spleen weight compared to the vehicle group (p < 0.01 and p < 0.0001, respectively; Figure 3D). This evidence concerns the gene MPO and Splenomegaly.