Of note, eleven out of fifteen up-modulated genes (END-1, TGF-β, VEGF, CXCL-1, CXCL-16, IL-6, IL-8, MMP-2, MMP-19, TIMP-2, and N-cad) reached a higher statistical significance in the case of CAFs, demonstrating that this type of cells, in addition to having a higher basal level of expression of genes involved in melanoma progression, are more prone to address melanoma cell requirements when stimulated by their secretome. The gene discussed is CXCL16; the disease is melanoma.