Of note, eleven out of fifteen up-modulated genes (END-1, TGF-β, VEGF, CXCL-1, CXCL-16, IL-6, IL-8, MMP-2, MMP-19, TIMP-2, and N-cad) reached a higher statistical significance in the case of CAFs, demonstrating that this type of cells, in addition to having a higher basal level of expression of genes involved in melanoma progression, are more prone to address melanoma cell requirements when stimulated by their secretome. This evidence concerns the gene TIMP2 and melanoma.