AXIN2 and cancer: AXIN2, although typically a negative regulator of the Wnt/β-catenin pathway, can act as a promoter of oncogenesis by enhancing Snail1-driven epithelial−mesenchymal transition (EMT), which contributes to cancer cell invasion and metastasis [60], and has been detected overexpressed in CRC tissues, mainly in the cytoplasm of tumor epithelial cells [61].