TP53 and neoplasm: A number of studies showed the ability of SLC5A8 to transport short-chain fatty acids and suggested the role of this transport in tumor suppression through the modulation of histone deacetylases (HDACs) [16], and, consequently, the alteration of the expression of numerous genes including p53, Bax, Bak, TRAIL, TRAILR1, TRAILR2, Survivin, Bcl2, and Bcl-W [46].