NF-κB acts as a lineage-defining transcription factor in MES GBM, where it cooperates with transcriptional regulators like STAT3, C/EBPβ, and FOSL1 to drive the mesenchymal gene expression program and promote inflammatory, invasive, and therapy-resistant features [39,40,41]. This evidence concerns the gene NFKB1 and glioblastoma.