ACE and allergic disease: In a 2014 study analyzing 716 patients with DHRs, Barenji et al. demonstrated that risk factors for drug allergy include the presence of coexisting allergic diseases (such as allergic asthma or allergic rhinitis) and the use of specific medications, particularly those prescribed for hypertension, including ACE inhibitors, angiotensin II receptor blockers, and beta-blockers, as well as antidepressants [61].