RNF213 R4810K coexisted with filamin A (FLNA) Gly1623Val fs*41 in a patient exhibiting Ehlers–Danlos-like symptoms and bilateral periventricular nodular heterotopia (PNH), but seizures and MMD-like cerebral vascular formation also appeared [189]. The gene discussed is FLNA; the disease is paroxysmal nocturnal hemoglobinuria.