IGF2 and myocardial infarction: Moreover, the regenerative P1 heart retained developmental and cell-cycle gene programs, within which an RNA-binding protein, IGF2BP3 (insulin-like growth factor 2 mRNA-binding protein), was identified to promote CM proliferation and restore cardiac morphology and function after MI, possibly driven by translational activation of CM regenerative factor mRNAs such as IGF2 (insulin-like growth factor 2) among other target mRNAs through the binding of 3′-UTR.