Downregulation of genes linked to Ehlers–Danlos and Loeys–Dietz syndromes suggests that the pathogenesis of aortic dissection in Myh11 K1256del mice and patients with FTAAD may show similarities to the pathogenesis of Ehlers–Danlos and Loeys–Dietz syndromes. This evidence concerns the gene MYH11 and Aortic dissection.