Additionally, probiotics can also suppress metastasis and angiogenesis, reduce oxidative stress by inhibiting cytokine production, and modulate signaling pathways, such as nuclear factor erythroid 2-related factor 2 (Nrf-2), NF-κB, and MAPK, thus allowing them to exert their beneficial antioxidant effects on cancer patients. This evidence concerns the gene NFKB1 and cancer.