This phenotypic shift leads these cells to produce growth factors (GFs), i.e., TGF-β and VEGF, helping in tumor progression, which activate nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) to promote cancer cell stemness, and the synthesis of matrix metalloproteinases to support metastasis formation [70]. Here, TGFB1 is linked to neoplasm.