ROR1 and glioblastoma: Moreover, in glioblastoma, the binding of insulin-like growth factor-binding protein 5 (IGFBP5) to ROR1 facilitates the formation of a ROR1/HER2 heterodimer, which subsequently induces the expression of genes like ETV5 and FBXW9 to promote glioblastoma stem-like cell invasion and tumorigenesis [25].