IGHE and Alzheimer disease: Furthermore, although LDHhigh subjects presented elevated HDM- and staphylococcal enterotoxin B (SEB)-specific and total IgE levels in their plasma compared to LDHlow patients (Figure 3E–G), the extent of patients’ HDM and SEB sensitization and their overall allergic status were significantly heightened in both AD subgroups in comparison with the controls (Table S1).