Since total IgE, circulating eosinophil count and disease severity strongly correlate with serum LDH in AD [4,5,20,21], we explored whether stratifying the same cohort of patients based on the median levels of these clinical parameters may reveal AD subgroups with similar CLA+ T-cell-mediated cytokine responses as defined by serum LDH classification. This evidence concerns the gene SELPLG and Alzheimer disease.