Taken together, finding that HDM-induced CLA+ memory T-cell production levels of IL-13, IL-5 and IL-9 are linked with the clinical features of LDHhigh patients is of translational relevance, since a recent report—in which the researchers performed TCR sequencing—demonstrated that allergen-specific CLA+ T-cell clones infiltrating AD skin lesions correspond to the circulating CLA+ T cells found in peripheral blood [38]. This evidence concerns the gene IL13 and Alzheimer disease.