Gaetani et al. recruited patients with PD, AD, or other neurological diseases and examined the co-occurrence of the two proteinopathies and their correlation with markers of synaptic dysfunction, namely synaptosomal-associated protein 25 kDa (SNAP25) and vesicle-associated membrane protein 2 (VAMP2), in CSF and plasma [45]. This evidence concerns the gene SNAP25 and Alzheimer disease.