MAPT and early-onset autosomal dominant Alzheimer disease: Additionally, genes involved in the AMP-activated protein kinase (AMPK) pathway have been linked to Alzheimer’s disease risk through their role in regulating energy balance, as well as glucose and lipid metabolism [86], autophagy dysfunctions leading to Aβ and tau pathology [84], and alteration of the synaptic plasticity of hippocampal neurons [87].