Meanwhile, certain circulating biomarkers, such as matrix Gla protein, fetuin A, fibroblast growth factor 23, calciprotein particles and bone-related proteins (osteoprotegerin, osteopontin, sclerostin), have been suggested for prediction of plaque shaping and atherosclerosis severity in patients with CKD G3–5, but not in those with CKD G1–2 [14,15,16]. Here, SPP1 is linked to chronic kidney disease.