YAP1 and cancer: NUAK2, a frequently amplified gene in tumors including breast cancer, and the related NUAK1, have been shown to inactivate the Hippo kinase cassette to promote tumorigenesis in breast, liver (NUAK2) and colorectal (NUAK1) cancers, as well as in driving fibrosis (NUAK1) in kidney and other tissues in a YAP-dependent manner [23,48,49,50].