SAV1 and ciliopathy: A few hits common to both cell lines, but detected in only one screen type, include NEK2 (in the localization assay), which was shown to interact directly with the Hippo pathway components SAV1 and MST1/2 to regulate centrosome disjunction [34] and NEK8 (in the TEAD-reporter assay), a ciliopathy gene that inhibits LATS-mediated phosphorylation of TAZ [35].