WWTR1 and cancer: We previously showed that NUAK2 negatively regulates the Hippo cassette by phosphorylating and inactivating LATS1/2 [18] and that chemical inhibition of NUAK2 restores Hippo pathway activity, suppresses YAP/TAZ and inhibits the growth of cancer cell lines in vitro and in mammary tumors in mice [18], with others showing similar results in liver cancer [19].