FAM175B exhibited a 1.61-fold increase (p = 0.0073), LRRTM4 presented a 2.23-fold increase (p = 0.0025), PROM2 presented a 2.11-fold increase (p = 0.0059), and PTPN22 presented the most pronounced increase, 3.04-fold (p < 0.0001), confirming robust transcriptional alterations in DCM. Here, PTPN22 is linked to familial dilated cardiomyopathy.