Glibenclamide reverses ROS production and caspase-1 activity induced by a high-fat diet, downregulates the TGF-β1-pSmad2/3-NLRP3 signaling pathway, inhibits profibrotic factors such as MMP-9, and alleviates myocardial fibrosis [42]. The gene discussed is CASP1; the disease is Myocardial fibrosis.