TP53 and glioblastoma: In the present study, using in vitro models of GSCs and their differentiated counterparts, we addressed this question and revealed that domatinostat induces BAX expression through both p53-dependent and -independent pathways, preferentially in GSCs, highlighting a novel mechanism of action of domatinostat against GSCs, which are considered one of the root causes of poor prognosis in glioblastoma.