Missense variants associated with the effect of BMI on asthma and COPD were identified in SLC39A8, POC5, anaphase promoting complex subunit 4 (ANAPC4), and SH2B1, along with a 3’UTR variant in FAIM2 (only COPD) and adenylate cyclase 9 (ADCY9), a 5’UTR variant in G protein-coupled receptor 61 (GPR61), a synonymous variant in TAO kinase 2 (TAOK2), and several genes with intronic variants (Supplementary Files S3 and S4). Here, ANAPC4 is linked to chronic obstructive pulmonary disease.