Missense variants in alcohol dehydrogenase 1B (Class I) (ADH1B), protein phosphatase 2 regulatory subunit B (PPP2R2D), and ANAPC4; 3’UTR variants in member RAS oncogene family (RAB30), argonaute RISC catalytic component 2 (AGO2), Huntingtin (HTT), electron transfer flavoprotein alpha subunit (ETFA), and nuclear fragile X mental retardation-interacting protein 2 (NUFIP2); and many genes with intronic variants were associated with the effect of alcohol intake frequency on asthma and COPD (Supplementary Files S6 and S7). The gene discussed is AGO2; the disease is chronic obstructive pulmonary disease.