While additional SNPs linked to the association of BMI, body fat percentage, fat-free mass, and alcohol with asthma and COPD were identified to be missense variants in several genes (e.g., ENPP2, ANAPC4, NCOR2, SH2B1, AATK, ADH1B, PPP2R2D, and ANAPC4), as well as 3’UTR (e.g., ZC3H4, ADCY9, RAB30, AGO2, HTT, ETFA, SNU13, FAIM2, TP53, NUFIP2, and KDM2A) and 5’UTR variants (GPR61), these SNPs have not been extensively documented in CRDs, thus elucidating a potential direction for further functional research. This evidence concerns the gene SH2B1 and chronic obstructive pulmonary disease.