Missense variants in alcohol dehydrogenase 1B (Class I) (ADH1B), protein phosphatase 2 regulatory subunit B (PPP2R2D), and ANAPC4; 3’UTR variants in member RAS oncogene family (RAB30), argonaute RISC catalytic component 2 (AGO2), Huntingtin (HTT), electron transfer flavoprotein alpha subunit (ETFA), and nuclear fragile X mental retardation-interacting protein 2 (NUFIP2); and many genes with intronic variants were associated with the effect of alcohol intake frequency on asthma and COPD (Supplementary Files S6 and S7). This evidence concerns the gene ETFA and chronic obstructive pulmonary disease.