Interestingly, the 22q11.2DS participants with psychotic features had higher levels of IL-6 (p < 0.001) and the IL-6/IL-10 ratio (an indicator of a proinflammatory state) compared to the non-psychotic 22q11.2DS individuals; furthermore, IL-6 levels and the IL-6/IL-10 ratio correlated with the severity of cognitive deficits. Here, IL6 is linked to Cognitive impairment.