Observational and case–control studies have found several general inflammatory biomarkers in PANDAS/PANS, including complement activation (high C4a and low C4), leukopenia, increased C-reactive protein, Neuron-specific Enolase (NSE), and serum amyloid A (SAA) [50,205,220,221,222]. The gene discussed is CRP; the disease is Decreased total leukocyte count.