The CSF of MS patients with higher levels of GM damage at diagnosis showed a proinflammatory pattern of elevated levels of molecules linked to sustained B-cell activity and lymphoid neogenesis, such as CXCL13, IL6, IL8, and IL10; proinflammatory cytokines, such as TNF and IFNγ; and high levels of BAFF, APRIL, LIGHT, TWEAK, sTNFR1, sCD163, MMP2, and pentraxin III [130]. Here, CD163 is linked to myeloid sarcoma.