It has been recently reported that the pro-inflammatory molecule, named inorganic polyphosphate (iPolyP), is upregulated in neoplastic CRC tissues compared to the corresponding normal counterpart and contributes to the development and progression of CRC via its binding receptor called transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8) [34]. The gene discussed is TRPM8; the disease is colorectal carcinoma.