Both iPolyP and the receptor TRPM8 are gathering attention in CRC pathophysiology nowadays, because while the former might be described as food additive, deriving from the intestinal microbiota or released by cellular organelles within the TME and promote a pro-inflammatory niche favorable for tumor growth [45], the latter has been associated with poor prognosis in CRC subjects, where it has been found to be overexpressed [46]. The gene discussed is TRPM8; the disease is colorectal carcinoma.