Thus, we tested the expression of several well-characterized EMT markers, such as Epithelial cadherin, Neural cadherin [47],Vimentin [48], phospho-Cofilin [49], Matrix Metalloprotease-2 [50], Alpha Smooth Muscle Actin [51], Type 1 Collagen [52], Connective Tissue Growth Factor [53], Fibronectin [54], and Filamentous Actin [55] in the presence or absence of iPolyP and TRPM8 inhibitor in a CRC cell line and CRC cell line-derived spheroids, as well as in CRC-patient derived organoids. Here, CCN2 is linked to colorectal carcinoma.