It has been recently shown that inorganic polyphosphatase enzyme (ppx1), upregulated in CRC and known to hydrolyze long iPolyP chains into smaller chains, can activate the phosphatidylinositol 3-kinase/Protein kinase B (PI3K/AKT) pathway [63], which exhibited pivotal regulatory tasks in the EMT development [64], although the evidence remains indirect. Here, AKT1 is linked to colorectal carcinoma.