Yang et al. developed a novel dual-targeting micellar delivery system (C3 peptide and triphenylphosphonium-modified nanomicelles, CT-NM) for resveratrol—a potent sirtuin 1 (SIRT1) activator with antioxidant, anti-inflammatory, and neuroprotective properties—to address mitochondrial dysfunction in Alzheimer’s disease (AD). This evidence concerns the gene SIRT1 and Alzheimer disease.