Among 51 individuals with gastric cancer, pathogenic or likely pathogenic variants were detected in 35% (18/51) cases, with a notable enrichment in genes associated with DDR, including ATM, ATR, BRCA2, BRCA1 interacting protein C-terminal helicase 1 (BRIP1), Fanconi Anemia complementation group C (FANCC), and TP53. The gene discussed is ATR; the disease is gastric cancer.