TNF and early-onset autosomal dominant Alzheimer disease: In addition, a randomized controlled trial recruiting participants with newly diagnosed Alzheimer’s disease who consumed 1.25 mg/day of FA for 6 months showed that the intervention group had significantly higher scores on the mini-mental state examination, which may be associated with reduced levels of inflammation biomarkers TNF-α and TNF-α-mRNA as well as Ab-related biomarkers Ab-40 and PS1-mRNA [130].