NPPB and cardiac hypertrophy: Systolic BP ↓; cardiac hypertrophy (calcineurin ↓; NFAT ↓; heart wt/body wt ↓; contractility ↓; myocyte area ↓; ANF ↓; BNP ↓); inflammation (CD68+ area ↓; IL-6 ↓; IL-1b ↓; TNF-α ↓, NF-κB ↓; TGF-β ↓); fibrosis (a-SMA ↓; Col I ↓; Col III ↓)