At the same time, the inhibition of PGC-1α, Nrf-1, Nrf-2, Tfam, Keap1, and HO-1 expression likely contributes to the reduction in oxidative stress and mitochondrial biogenesis [34], thereby mitigating the liver damage caused by PHS and providing a certain therapeutic effect. The gene discussed is HMOX1; the disease is Pallister-Hall syndrome.