The obese psoriatic patient is also characterized by chronic pro-inflammatory cytokines and adipokines that are generated by white fat adipocytes; high levels of IL-17, IL-23, TNF, and interferon (IFN) were reported to support the gut microbiome–obesity relationship in Pso patients [36,37,38,39]. This evidence concerns the gene IL17A and obesity due to melanocortin 4 receptor deficiency.