At the family level, Lachnospiraceae, Erysipelotrichaceae, and Bacteroidaceae, which were enriched in the obesity-related groups, either with or without Pso, displayed positive correlations with all the investigated proinflammatory cytokines and chemokines, except IL-10 and PF4 (Supplementary Materials, Figure S4). Here, PF4 is linked to obesity due to melanocortin 4 receptor deficiency.