Treatment with TRF ↓ gene expression in the mRNA processing, epidermal growth factor receptor (EGFR1), p53, the PI3K-Akt-mTOR, NF-kB, T cell receptor, TNF-alpha, and mitogen-activated protein kinase (MAPK) signalling pathways in the APPswe/PS1dE9 transgenic AD mice model group compared to the untreated ones. The gene discussed is NFKB1; the disease is Alzheimer disease.