TRF interfered with the aggregation of Aβ42 in human neuroblastoma cells without reducing cell viability. Compared to the untreated group, AβPP/PS1 mice ↑ cognitive performance following TRF supplementation. TRF treatment ↓ amyloid beta deposition in the brains of APP/PS1 mice. However, TRF had no significant effect on microglial activation. This evidence concerns the gene APP and neuroblastoma.