TRF treatment ↑ overlapping expression of APP and PTPRA in the hippocampus of transgenic mice than in the untreated group. TRF treatment also altered the expression of metabolic system proteins related to AD, PD, Huntington’s disease, and oxidative phosphorylation in APPswe/PS1dE9 double transgenic mice compared to the untreated group. Here, PTPRA is linked to juvenile Huntington disease.