The main TFs involved in lung cancer progression are Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), p53, Hypoxia-inducible factor 1 (HIF-1), MYC, and Activator Protein-1 (AP-1), and their abnormal activation or loss of normal function can promote cancer development and spread [34]. This evidence concerns the gene JUN and cancer.