At the same time nc-RNAs such HOTAIR and LncRNA-p21 respond to oxidative stress by altering their cellular abundance, thereby regulating gene expression networks involved in ROS balance, or suppressed by these same transcription factors, playing a key role in activating signalling pathways that lead to a tumor-friendly environment for metastasis and uncontrolled growth [86,87]. The gene discussed is HOTAIR; the disease is neoplasm.