Another lncRNA overexpressed in lung cancer and involved in tumour progression is HOTAIR (HOX Transcript Antisense Intergenic RNA), which modulates the immune response to the tumour and influences the polarisation of macrophages towards the pro-tumour M2 phenotype; this results in an immunosuppressive microenvironment that promotes tumour growth [62,64]. This evidence concerns the gene HOTAIR and neoplasm.