VEGFA and wet macular degeneration: In wet AMD, inflammatory factors are overexpressed, as hypoxia inducible factor 1 (HIF-1) triggers the release of several pro-angiogenic factors, notably vascular endothelial growth factor A (VEGF-A), alongside angiopoietin 2, platelet-derived growth factor (PDGF), and fibroblast growth factor 2 (FGF2) [5].