The frequent concurrence of various pathologies in DLB, in particular with ADNC and TDP-43 pathology, is probably due to a complex interaction of various pathological proteins, like tau, Aβ, αSyn, or TDP-43, that concur with aging [17,24,50,144,218] and affect multiple molecular pathways and interrelated pathobiological mechanisms. Here, TARDBP is linked to Lewy body dementia.