BIN1 and Alzheimer disease: In a series of autopsy-proven cases of DLB (and PD), the best-fit generated risk score for ADNC based on age of disease onset and genotype at three SNPs (single-nucleotide polymorphisms) (APOE, BIN1, and SORL1 loci) provided a simple model incorporating three AD-risk SNPs for detecting concomitant AD pathology [161].