TARDBP and amyotrophic lateral sclerosis: Cytoplasmic inclusion bodies containing phosphorylated and truncated forms of TDP-43 are morphological hallmarks of amyotrophic lateral sclerosis (ALS) and a subset of frontotemporal lobe degeneration (FTLD-TDP), but they have also been identified in AD [75] and in other age-related neurodegenerative disorders, referred to as limbic-predominant age-related TDP-43 encephalopathy (LATE) [36].