In the diagnostic setting, blood- and urine-based tests such as the PHI, the 4Kscore, SelectMDx, PCA3, and circulating tumor cells offer greater specificity than PSA alone, particularly in men with PSA levels between 2 and 10 ng/mL [20,46,51,102,103,104,105]. This evidence concerns the gene KLK3 and neoplasm.