Our results show that altered consciousness and autonomic dysfunction, focal/generalized slowing or epileptiform abnormalities in the first EEG, specific MRI (myelitis), higher scores on the modified Rankin Scale at admission, and intrathecal IgM synthesis in the CSF analysis according to Reiber’s graph were associated with poorer outcomes. The gene discussed is CD40LG; the disease is Abnormal autonomic nervous system physiology.