EPAS1 and focal segmental glomerulosclerosis: Supporting this, Luque et al. demonstrated that endothelial-specific deficiency of EPAS1 in a hypertensive mouse model led to the loss of glomerular endothelial cell fenestration, increased endothelial swelling, and progressive glomerulosclerosis, including the development of focal segmental glomerulosclerosis (FSGS) [28].