Curcumin, a natural polyphenol, directly suppresses NLRP3 inflammasome assembly and downregulates TLR4/myeloid differentiation primary response 88/nuclear factor-κB (TLR4/MyD88/NF-κB) pathways in CKD-related models, leading to decreased oxidative stress and inflammatory cytokine production [66]. The gene discussed is TLR4; the disease is chronic kidney disease.