The medians of DAMPs and inflammatory mediators in children with SIRS were higher than in children who did not have SIRS: HMGB-1, 2099 vs. 1459 pg/mL (Figure 4A); S100A8, 41.28 vs. 23.30 pg/mL (Figure 4B). Here, HMGB1 is linked to systemic inflammatory response syndrome.