In relation to the delta values of the biomarkers in patients with and without SIRS, important differences were found, with statistically higher medians in patients with SIRS compared to those without SIRS of ∆ HMGB1 [3.58 (0.26–6.5) vs. 0.6 (−1.1–6.5)], ∆ IL-8 [0.3 (−4–0.05) vs. −2 (−8–0.05)], ∆ IL-10 [0.63 (0.21–0.94) vs. 0.08 (−0.19–0.28)], ∆ IL-1β [0.19 (−3.4–0.73 vs. −1.79 (−8–0.1)], and ∆ MCP1 [0.55 (0.22–0.74) vs. 0.42 (0.28–0.95)], * p < 0.05 (Figure 7). The gene discussed is HMGB1; the disease is systemic inflammatory response syndrome.