Therefore, the aim of the present study was to identify the association of DAMPs, such as HMGB1 and S100A8, and inflammatory mediators, such as TNF-α, IL-8, IL-10, IL-1β, IL-6, and MCP1, in the development of systemic inflammatory response in pediatric patients with recently diagnosed ALL. This evidence concerns the gene S100A8 and acute lymphoblastic leukemia.