TNF and systemic inflammatory response syndrome: Inflammatory mediators in children with SIRS were higher than in children who did not have SIRS, such as TNF-α, 135.73 vs. 97.52 (Figure 5A); IL-8, 185.73 vs. 69.19 (Figure 5B); and IL-10, 564.27 vs. 81.21 pg/mL (Figure 5C).