The novelty of this work is the association of DAMPs (HMGB1) and inflammatory mediators (IL-8, IL-10, IL1-β, and MCP-1) in the development of systemic inflammatory response (SIRS) in pediatric patients with newly diagnosed acute lymphoblastic leukemia (ALL) and no apparent clinical infection. This evidence concerns the gene CXCL8 and acute lymphoblastic leukemia.