Analysis of CSF from NPC1 patients has revealed altered levels of various inflammatory markers, including increased interleukin 3 (IL-3), chemokine (C-X-C motif) ligand 5 (CXCL5), interleukin 16 (IL-16), and chemokine ligand 3 (CCL3), alongside decreased levels of anti-inflammatory cytokines like IL-4, IL-10, and IL-13 [86]. The gene discussed is IL16; the disease is Niemann-Pick disease, type C1.