Using a murine multistep chemical carcinogenesis model, researchers studied a soluble VEGF-C/VEGF-D inhibitor and found that both VEGF-C and VEGF-D contribute to an inflammatory tumor microenvironment promoting early tumor progression, while VEGF-D also drives lympho-angiogenesis and late-stage metastasis via VEGFR-3 signaling [114]. Here, FLT4 is linked to neoplasm.