These observations parallel those obtained in skin biopsies collected from BCC and cSCC patients demonstrating that BBC express higher levels of type 2 cytokines as IL-4 and IL-10 compared to normal skin and that the cellular source of these cytokines are cells depleted on non-adherent lymphocytes, probably a mix of macrophages and tumor cells adhered to cell plates. This evidence concerns the gene IL4 and skin basal cell carcinoma.