The presence into the tumor of IL-10 indicated the presence of the M2a and/or M2c subset even if later on, other authors reported also that the presence of high levels of VEGF-C in SCC lesions is associated with the presence of CD163+ and/or CD68+ peritumoral macrophages strongly suggesting that TAMs may also display a M2d phenotype [18]. This evidence concerns the gene VEGFC and neoplasm.