A study by Park et al. demonstrated changes in histone acetylation (HATs) and deacetylation enzymes (HDACs) involved in the regulation of the alpha-synuclein gene (SNCA) that were unique to the SNpc of Parkinson’s patients, suggesting a potential dysregulation of gene transcription underlying the accumulation of aS in this cohort [24]. The gene discussed is SNCA; the disease is Parkinson disease.